Acute anosmia in neuromyelitis optica spectrum disorder. (December 2020)

• Record Type: Journal Article
• Authors: Marshall, Joseph; Kleerekooper, Iris; Davagnanam, Indran; Trip, S Anand
• Is Part Of: Multiple sclerosis. Volume 26:Number 14(2020)
• Page Start: 1958
• Page End: 1960
• Publication Date: 2020-12
• Subjects: Neuromyelitis optica (NMO) -- T2 lesions -- magnetic resonance imaging (MRI); Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458520907909
• Languages: English
• ISSNs: 1352-4585

Abstract

The cardinal features of neuromyelitis optica spectrum disorder (NMOSD) are optic neuritis, longitudinal extensive transverse myelitis and area postrema syndrome. Olfactory dysfunction is not listed as a feature in the NMOSD diagnostic criteria. Here, we present an aquaporin-4 antibody positive patient who, in addition to classical features of NMOSD, developed acute anosmia with magnetic resonance imaging (MRI) evidence of olfactory bulb abnormalities. While the association of anosmia and NMOSD has been rarely noted previously, to our knowledge, no prior cases have found this to be one of the presenting features of a relapse nor have they identified acute radiological correlates.