A comparison of single dose dexmedetomidine with propofol for the prevention of emergence delirium after desflurane anaesthesia in children. (7th October 2015)

• Record Type: Journal Article
• Authors: Makkar, J. K.; Bhatia, N.; Bala, I.; Dwivedi, D.; Singh, P. M.
• Is Part Of: Anaesthesia. Volume 71:Number 1(2016:Jan.)
• Page Start: 50
• Page End: 57
• Publication Date: 2015-10-07
• Subjects: Anesthesia -- Periodicals; 617.96
• DOI: 10.1111/anae.13230
• Languages: English
• ISSNs: 0003-2409

Abstract

Summary: Emergence delirium is a common problem in children recovering from general anaesthesia. We performed a study comparing emergence characteristics in 100 patients who were randomly allocated to receive either 0.3 μg.kg −1 dexmedetomidine, 1 mg.kg −1 propofol or saline 0.9% and undergoing infra‐umbilical surgery. The Pediatric Anesthesia Emergence Delirium scale was used to grade emergence delirium. Emergence delirium occurred in 9.4% of children in the dexmedetomidine group compared with 13.9% in the propofol group and 40.6% in the control group (p = 0.004). In the dexmedetomidine group, sedation occurred in 62.5% of children at 10 min after transfer to the recovery area, compared with 44.4% in the propofol group and 12.5% in the control group (p = 0.010). We conclude that dexmedetomidine significantly reduced the incidence of emergence delirium but this was at the expense of a greater incidence of sedation in the recovery period.