A sirtuin activator and an anti-inflammatory molecule—multifaceted roles of adjudin and its potential applications for aging-related diseases. (November 2016)

• Record Type: Journal Article
• Authors: Xia, Weiliang; Geng, Keyi
• Is Part Of: Seminars in cell & developmental biology. Volume 59(2016)
• Page Start: 71
• Page End: 78
• Publication Date: 2016-11
• Subjects: Adjudin 1-(2, 4-dichlorobenzyl)-1H-indazole-3-carbohydrazide -- ANT adenine nucleotide translocator -- CSC cancer stem cell -- EMT epithelial-mesenchymal transition -- IDH isocitrate dehydrogenase -- AIF apoptosis inducing factor -- VEGF vascular endothelial growth factor -- CI combination index -- IC 50half maximal inhibitory concentration -- MDR multidrug resistance -- DSPE-PEG20001 2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] -- NSAID non-steroidal anti-inflammatory drugs -- PGE2 prostaglandin E2 -- NO nitric oxide -- NF-κkappaB nuclear factor kappa B -- CNS central nervous system -- ROS reactive oxygen species -- LPS lipopolysaccharide -- IL interleukin -- ERK extracellular signal-regulated kinase -- TNFαalpha tumor necrosis factor alpha -- iNOS inducible nitric oxide synthase -- COX-2 cyclooxygenase-2 -- pMCAO permanent middle cerebral artery occlusion -- tMCAO transient middle cerebral artery occlusion -- tPA tissue plasminogen activator -- BBB blood-brain barrier -- FSH follicle-stimulating hormone -- LH luteinizing hormone -- JAM-A junctional adhesion molecule-A -- MMP matrix metalloproteinase -- Sir2 silent information regulator 2 -- CR caloric restriction; Adjudin -- Anti cancer -- Anti-inflammation -- NF-kB -- SIRTUIN -- Activator -- Stroke -- Aging; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2016.07.020
• Languages: English
• ISSNs: 1084-9521

Abstract

Abstract: Adjudin was originally developed as an improved analog of lonidamine to serve as a non-hormonal reversible male contraceptive that could cause exfoliation of the immature sperms from the seminiferous epithelium. Recently, the functionality spectrum of adjudin expands beyond as an anti-spermatogenic agent, namely, it could function as an anti-cancer drug potentially useful for combination chemotherapy, and as an anti-inflammatory molecule that could protect against ischemic stroke injury. Most strikingly, adjudin acts through activation of mitochondrion-located Sirt3 to safeguard hair cells of the cochlea from ototoxicant such as gentamycin. Recent studies also indicate that adjudin could attenuate oxidative stress and cellular senescence. These findings suggest wider applications of this small molecule, particularly in aging-related diseases.