Thyroglobulin levels and thyroglobulin/thyrotropin ratio could predict the success of the ablative/therapeutic 131I in the differentiated thyroid cancers. (2nd January 2017)

• Record Type: Journal Article
• Authors: Trevizam, Paula Grasiele Carvalho; Tagliarini, José Vicente; Castilho, Emanuel Celice; de Alencar Marques, Mariângela; Kiy, Yoshio; Mazeto, Gláucia Maria Ferreira da Silva
• Is Part Of: Endocrine research. Volume 42:Number 1(2017)
• Page Start: 42
• Page End: 48
• Publication Date: 2017-01-02
• Subjects: Biological markers -- prognosis -- thyroglobulin -- thyroid neoplasms -- thyrotropin; Endocrinology, Experimental -- Periodicals; Endocrinology -- Periodicals; Endocrinology -- Periodicals; Research -- Periodicals; 616.4
• DOI: 10.3109/07435800.2016.1173056
• Languages: English
• ISSNs: 0743-5800

Abstract

ABSTRACT: Background : Stimulated thyroglobulin (STg) levels in patients with differentiated thyroid carcinomas (DTCs) after total thyroidectomy (TT) and before radioactive iodine ( 131 I) ablation/therapy (RIT) are predictive of therapeutic success but can be influenced by the thyroid-stimulating hormone (TSH) level. Objectives : This study compared the reliability of the STg/TSH ratio and STg measurement in predicting the success of RIT. Methods : Sixty-three DTC patients submitted to TT were assessed retrospectively to compare the ability of STg level and the STg/TSH ratio to predict successful RIT. Results : In this study 48 (76.2%) patients had successful RIT. The successful and unsuccessful groups received different 131 I doses and had different STg levels and STg/TSH ratios. The STg and STg/TSH ratio cutoff values that predicted successful RIT were 4.41 ng/mL (sensitivity of 86.7% and specificity of 77%) and 0.093 (sensitivity of 80% and specificity of 79.2%), respectively. Age, STg level, STg/TSH ratio, and 131 I dose were associated with successful RIT, but after multivariate analysis only STg remained associated ( p < 0.05). Conclusion : In conclusion, our data suggest that the STg/TSH ratio and measurement of STg are equally reliable in predicting successful RIT in DTC patients.