Γ-Glutamyl-dipeptides: Easy tools to rapidly probe the stereoelectronic properties of the ionotropic glutamate receptor binding pocket. Issue 51 (22nd December 2016)

• Record Type: Journal Article
• Authors: Tamborini, Lucia; Nicosia, Veronica; Conti, Paola; Dall'Oglio, Federica; De Micheli, Carlo; Nielsen, Birgitte; Jensen, Anders A.; Pickering, Darryl S.; Pinto, Andrea
• Is Part Of: Tetrahedron. Volume 72:Issue 51(2016)
• Page Start: 8486
• Page End: 8492
• Publication Date: 2016-12-22
• Subjects: Glutamic acid -- Dipeptides -- Ionotropic glutamate receptors -- Flow-chemistry -- Polymer-supported reagents; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2016.11.025
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: γ-Glutamyl-dipeptides, built by condensing the distal carboxylate of l -Glu (or d -Glu) onto a series of differently functionalized amino acids, were prepared and used as tools for rapidly probing the stereo-electronic properties of iGluRs, searching for subtype-selective ligands. Graphical abstract: