Β-Catenin-Independent Roles of Wnt/LRP6 Signaling. Issue 12 (December 2016)

• Record Type: Journal Article
• Authors: Acebron, Sergio P.; Niehrs, Christof
• Is Part Of: Trends in cell biology. Volume 26:Issue 12(2016)
• Page Start: 956
• Page End: 967
• Publication Date: 2016-12
• Subjects: post-transcriptional Wnt signaling -- Wnt/STOP -- β-catenin -- mitosis -- proteolysis -- GSK3; Cytology -- Periodicals; Cytology -- Research -- Periodicals; 571.6
• DOI: 10.1016/j.tcb.2016.07.009
• Languages: English
• ISSNs: 0962-8924

Abstract

Abstract : Wnt/LRP6 signaling is best known for the β-catenin-dependent regulation of target genes. However, pathway branches have recently emerged, including Wnt/STOP signaling, which act independently of β-catenin and transcription. We review here the molecular mechanisms underlying β-catenin-independent Wnt/LRP6 signaling cascades and their implications for cell biology, development, and physiology. Trends: Wnt/LRP6 signaling is thought to proceed by β-catenin mediated transcription. However, this pathway branches off to trigger a variety of other processes, revising the traditional transcription-centric view. Wnt/STOP signaling is one such novel branch of Wnt/LRP6 signaling, which peaks during mitosis to slow down protein degradation as cells prepare to divide. Transcription-independent Wnt/LRP6 signaling regulates cell growth and mitotic progression in dividing cells, axonal remodeling in post-mitotic neurons, and maturation of germ cells.