Healthcare-associated Gram-negative bloodstream infections: antibiotic resistance and predictors of mortality. Issue 4 (December 2016)

• Record Type: Journal Article
• Authors: Ergönül, Ö.; Aydin, M.; Azap, A.; Başaran, S.; Tekin, S.; Kaya, Ş.; Gülsün, S.; Yörük, G.; Kurşun, E.; Yeşilkaya, A.; Şimşek, F.; Yılmaz, E.; Bilgin, H.; Hatipoğlu, Ç.; Cabadak, H.; Tezer, Y.; Togan, T.; Karaoğlan, İ.; İnan, A.; Engin, A.; Alışkan, H.E.; Yavuz, S.Ş.; Erdinç, Ş.; Mulazimoglu, L.; Azap, Ö.; Can, F.; Akalın, H.; Timurkaynak, F.
• Is Part Of: Journal of hospital infection. Volume 94:Issue 4(2016)
• Page Start: 381
• Page End: 385
• Publication Date: 2016-12
• Subjects: Bloodstream -- Gram-negative -- Healthcare; Cross infection -- Periodicals; Cross infection -- Prevention -- Periodicals; Nosocomial infections -- Periodicals; Nosocomial infections -- Prevention -- Periodicals; Cross Infection -- Periodicals; Cross Infection -- prevention & control -- Periodicals; Infection Control -- Periodicals; Electronic journals; 614.44
• DOI: 10.1016/j.jhin.2016.08.012
• Languages: English
• ISSNs: 0195-6701

Abstract

Summary: This article describes the prevalence of antibiotic resistance and predictors of mortality for healthcare-associated (HA) Gram-negative bloodstream infections (GN-BSI). In total, 831 cases of HA GN-BSI from 17 intensive care units in different centres in Turkey were included; the all-cause mortality rate was 44%. Carbapenem resistance in Klebsiella pneumoniae was 38%, and the colistin resistance rate was 6%. Multi-variate analysis showed that age >70 years [odds ratio (OR) 2, 95% confidence interval (CI) 1.22–3.51], central venous catheter use (OR 2.1, 95% CI 1.09–4.07), ventilator-associated pneumonia (OR 1.9, 95% CI 1.1–3.16), carbapenem resistance (OR 1.8, 95% CI 1.11–2.95) and APACHE II score (OR 1.1, 95% CI 1.07–1.13) were significantly associated with mortality.