Application of Monodirectional Janus Patch to Oromucosal Delivery System. Issue 15 (8th September 2015)

• Record Type: Journal Article
• Authors: You, Jae Bem; Choi, Ah Young; Baek, Jieung; Oh, Myung Seok; Im, Sung Gap; Lee, Kyung Eun; Gwak, Hye Sun
• Is Part Of: Advanced healthcare materials. Volume 4:Issue 15(2015)
• Page Start: 2229
• Page End: 2236
• Publication Date: 2015-09-08
• Subjects: drug delivery -- initiated chemical vapor deposition (iCVD) -- Janus patch -- monodirectional -- oromucosa; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201500416
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : Drug delivery through mucosae has received huge research attention owing to its advantageous characteristics such as accurate dose control and the avoidance of premature metabolism of vulnerable drugs by oral administration. However, body fluid in mucosae may dissolve the drug, releasing it to unwanted directions. Here, a Janus drug delivery patch with monodirectional diffusion property is devised to deliver drugs efficiently and to overcome the issue of unwanted drug release. A polyester fabric is coated with a hydrophobic polymer, poly(3, 3, 4, 4, 5, 5, 6, 6, 7, 7, 8, 8, 9, 9, 10, 10‐heptadecafluorodecyl methacrylate), via initiated chemical vapor deposition. Subsequently, hydrophilicity is rendered selectively on one surface by base‐catalyzed hydrolysis to obtain a Janus substrate with both hydrophobic and hydrophilic surfaces. The hydrophilic surface of the Janus substrate is further coated with resveratrol‐loaded hydrogel to produce a Janus drug delivery patch. The fabricated patch efficiently blocks fluid penetration from one side to the other in mucous environment. Delivery of resveratrol through hairless mouse skin and reconstructed human mucosae using Janus patch shows higher permeation flux compared to bare control patch. The Janus drug delivery patch shown in this study can be a useful tool for efficient transmucosal delivery of various kinds of drugs. Abstract : Janus drug delivery patch with monodirectional diffusion property is devised using Janus substrate containing both hydrophobic and hydrophilic surfaces. Transmucosal delivery of resveratrol is successfully achieved using Janus patch with higher efficiency compared to bare control. The Janus patch shown here facilitates transmucosal delivery of easily metabolized drugs that otherwise are commonly administered orally.