Presynaptic long-term potentiation requires extracellular signal-regulated kinases in the anterior cingulate cortex. (April 2020)

• Record Type: Journal Article
• Authors: Chen, Qi-Yu; Zhang, Zhi-Ling; Liu, Qin; Chen, Chao-Jun; Zhang, Xiao-Kang; Xu, Ping-Yi; Zhuo, Min
• Is Part Of: Molecular pain. Volume 16(2020)
• Publication Date: 2020-04
• Subjects: Extracellular signal-regulated kinase -- mitogen-activated protein kinase -- anterior cingulate cortex -- postsynaptic long-term potentiation -- presynaptic long-term potentiation; Pain -- Molecular aspects -- Periodicals; Pain -- Pathophysiology -- Periodicals; Pain -- Physiological aspects -- Periodicals; 616.0472
• DOI: 10.1177/1744806920917245
• Languages: English
• ISSNs: 1744-8069

Abstract

Extracellular signal-regulated kinases are widely expressed protein kinases in neurons, which serve as important intracellular signaling molecules for central plasticity such as long-term potentiation. Recent studies demonstrate that there are two major forms of long-term potentiation in cortical areas related to pain: postsynaptic long-term potentiation and presynaptic long-term potentiation. In particular, presynaptic long-term potentiation in the anterior cingulate cortex has been shown to contribute to chronic pain-related anxiety. In this review, we briefly summarized the components and roles of extracellular signal-regulated kinases in neuronal signaling, especially in the presynaptic long-term potentiation of anterior cingulate cortex, and discuss the possible molecular mechanisms and functional implications in pain-related emotional disorders.