Metabolism in tumor microenvironment: Implications for cancer immunotherapy. Issue 1 (3rd June 2020)

• Record Type: Journal Article
• Authors: Shi, Rongchen; Tang, Yi‐Quan; Miao, Hongming
• Is Part Of: MedComm. Volume 1:Issue 1(2020)
• Page Start: 47
• Page End: 68
• Publication Date: 2020-06-03
• Subjects: cancer therapy -- immunity -- metabolism -- tumor microenvironment; 610
• DOI: 10.1002/mco2.6
• Languages: English
• ISSNs: 2688-2663

Abstract

Abstract: Tumor microenvironment is a special environment for tumor survival, which is characterized by hypoxia, acidity, nutrient deficiency, and immunosuppression. The environment consists of the vasculature, immune cells, extracellular matrix, and proteins or metabolic molecules. A large number of recent studies have shown that not only tumor cells but also the immune cells in the tumor microenvironment have undergone metabolic reprogramming, which is closely related to tumor drug resistance and malignant progression. Tumor immunotherapy based on T cells gives patients new hope, but faces the dilemma of low response rate. New strategies sensitizing cancer immunotherapy are urgently needed. Metabolic reprogramming can directly affect the biological activity of tumor cells and also regulate the differentiation and activation of immune cells. The authors aim to review the characteristics of tumor microenvironment, the metabolic changes of tumor‐associated immune cells, and the regulatory role of metabolic reprogramming in cancer immunotherapy. Abstract : Metabolic reprogramming is the basis of tumor microenvironment, which consists of cellular and extracellular components. The cellular components are mainly composed of hematopoietic immune cells (For example, TAMs, tumor‐associated macrophages; TILs, tumor‐infiltrated lymphocytes; TADCs, tumor‐associated dendritic cells; TANKs, tumor‐associated natural killer cells) and resident stromal cells. The extracellular components are mainly composed of extracellular matrix and cell‐secreted factors. The interaction between cancer cells and interstitial cells in the tumor microenvironment regulates tumorigenesis and progression.