SGK1 is a signalling hub that controls protein synthesis and proliferation in endothelial cells. Issue 19 (20th August 2020)

• Record Type: Journal Article
• Authors: Medina‐Jover, Ferran; Gendrau‐Sanclemente, Núria; Viñals, Francesc
• Is Part Of: FEBS letters. Volume 594:Issue 19(2020)
• Page Start: 3200
• Page End: 3215
• Publication Date: 2020-08-20
• Subjects: angiogenesis -- BMP9 -- ERK -- HHT -- protein synthesis -- SGK1; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.13901
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : BMP9 is a cytokine involved in the maturation phase of the angiogenic process that signals through its serine/threonine receptor ALK1 and its coreceptor endoglin. In this paper, we explain how BMP9 directs the regulation of endothelial cell proliferation blockage while in turn stimulating protein synthesis. To achieve this, BMP9 promotes SGK1 synthesis and activation through mTORC2 in order to stimulate the mTORC1/S6K/S6 axis. Moreover, BMP9 blocks proliferation also through SGK1 by reducing the activity of the MEK/ERK signalling pathway. Inhibition of SGK1 activity is sufficient to prevent BMP9‐mediated inhibition of ERK, leading to an increase in endothelial cell proliferation. Overall, our findings reveal that SGK1 is a key player during angiogenesis, mediating the pro‐quiescent and maturation effects of BMP9/ALK1. Abstract :