Alteration of sperm parameters and reproductive hormones in Swiss mice via oxidative stress after co‐exposure to titanium dioxide and zinc oxide nanoparticles. (16th July 2020)

• Record Type: Journal Article
• Authors: Ogunsuyi, Opeoluwa M.; Ogunsuyi, Olusegun I.; Akanni, Olubukola; Alabi, Okunola A.; Alimba, Chibuisi G.; Adaramoye, Oluwatosin A.; Cambier, Sebastien; Eswara, Santhana; Gutleb, Arno C.; Bakare, Adekunle A.
• Is Part Of: Andrologia. Volume 52:Number 10(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-07-16
• Subjects: oxidative stress -- reproductive hormones -- sperm parameters -- titanium dioxide NPs -- zinc oxide NPs; Andrology -- Periodicals; Infertility, Male -- Periodicals; 616.69
• DOI: 10.1111/and.13758
• Languages: English
• ISSNs: 0303-4569

Abstract

Abstract: In this study, Swiss male mice were intraperitoneally administered with titanium dioxide (TiO2 ) and zinc oxide (ZnO) nanoparticles (NPs) and their mixture (1:1) at doses between 9.38 and 75 mg/kg for 5 weeks to evaluate reproductive toxicity. Both NPs and their mixture significantly ( p < .001) altered sperm motility, reduced sperm numbers and increased abnormalities, while their mixture induced more sperm abnormalities than either TiO2 NPs or ZnO NPs. Both NPs and their mixture significantly ( p < .05) reduced the LH level, while ZnO NPs alone and their mixture ( p < .001) increased the testosterone levels at tested doses. The testes of exposed mice showed pathological changes and altered histomorphometrics. TiO2 NPs and ZnO NPs individually induced a significant ( p < .01) reduction in SOD and CAT activities, while the mixture significantly ( p < .001) decreased CAT activity and increased SOD activity. TiO2 NPs alone at 9.38 mg/kg induced a significant ( p < .001) reduction in the GSH level, while both NPs and their mixture increased the MDA level significantly ( p < .05). The data showed that the mixture had a synergistic interaction to induce testicular damage. Overall, oxidative stress may be involved in the NP‐mediated testicular damage observed.