Visible Light‐Induced Copper‐Catalyzed C—H Arylation of Benzoxazoles†. Issue 11 (1st August 2020)

• Record Type: Journal Article
• Authors: Ma, Xiaodong; Zhang, Guozhu
• Is Part Of: Chinese journal of chemistry. Volume 38:Issue 11(2020)
• Page Start: 1299
• Page End: 1303
• Publication Date: 2020-08-01
• Subjects: Photo‐induced -- Copper‐catalyzed -- Visible light -- Azole -- C—H arylation; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cjoc.201900527
• Languages: English
• ISSNs: 1001-604X

Abstract

Summary of main observation and conclusion: A general method for visible light‐induced copper‐catalyzed arylation of sp 2 C—H bonds of azoles has been developed. The method employs aryl halide as the coupling partner, lithium alkoxide as base. A variety of azoles including benzooxazole and benzothiazole can be arylated. Furthermore, electron‐poor heterocycles such as thiophene possessing one electron‐withdrawing group can also be arylated. Abstract : A general method for visible light‐induced copper‐catalyzed arylation of sp 2 C—H bonds of azoles has been developed. The method employs aryl halide as the coupling partner, lithium alkoxide as base. A variety of azoles including benzoxazole and benzothiazole can be arylated. Furthermore, electron‐poor heterocycles such as thiophene possessing one electron‐withdrawing group can also be arylated.