Vaccine Platforms: Biosynthesis of Self‐Assembled Proteinaceous Nanoparticles for Vaccination (Adv. Mater. 42/2020). Issue 42 (20th October 2020)

• Record Type: Journal Article
• Authors: Pan, Chao; Wu, Jun; Qing, Shuang; Zhang, Xiao; Zhang, Lulu; Yue, Hua; Zeng, Ming; Wang, Bin; Yuan, Zheng; Qiu, Yefeng; Ye, Huahu; Wang, Dongshu; Liu, Xiankai; Sun, Peng; Liu, Bo; Feng, Erling; Gao, Xiaoyong; Zhu, Li; Wei, Wei; Ma, Guanghui; Wang, Hengliang
• Is Part Of: Advanced materials. Volume 32:Issue 42(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-10-20
• Subjects: AB5 toxins -- biosynthesis -- conjugate vaccines -- nanovaccines -- self‐assembled proteins; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202070313
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : In article number 2002940, Li Zhu, Wei Wei, Guanghui Ma, Hengliang Wang, and co‐workers present a Nano‐B5 vaccine platform that is fully bio‐synthesized in bacteria. This self‐assembled platform serves as a versatile chassis to combine adjuvant modular and display peptide or polysaccharide antigens. Upon excellent lymph‐node targeting and immunoresponse elicitation in vivo, strong prophylactic effects and efficient therapeutic effects are achieved.