Comparison of the Prognostic Factors of Fetuses With Congenital Pulmonary Airway Malformations According to Type. (18th May 2020)

• Record Type: Journal Article
• Authors: Jeong, Ba‐Da; An, Su‐ah; Lee, Mi‐Young; Won, Hye‐Sung; Han, Minkyu; Yoon, Heemang; Lee, Ji‐Hoon; Cho, Yoon‐Jung
• Is Part Of: Journal of ultrasound in medicine. Volume 39:Number 11(2020)
• Page Start: 2243
• Page End: 2252
• Publication Date: 2020-05-18
• Subjects: congenital cystic adenomatoid malformation -- pregnancy outcome -- prenatal diagnosis -- prognostic factors -- ultrasound; Ultrasonics in medicine -- Periodicals; Ultrasonics; Ultrasonography; Ultrasonics in medicine; Electronic journals; Periodicals; Periodicals; 616.07543
• DOI: 10.1002/jum.15335
• Languages: English
• ISSNs: 0278-4297

Abstract

Abstract : Objectives: To compare the prognostic factors of fetuses with microcystic and macrocystic congenital pulmonary airway malformations (CPAMs). Methods: We retrospectively evaluated fetuses with CPAMs at Asan Medical Center. The CPAM size, mass effect, and maximum cyst size in macrocystic CPAMs were evaluated prenatally. The adverse postnatal outcomes, including respiratory symptoms, mechanical ventilation, and surgery, were evaluated. Results: In 118 cases, 2 fetal deaths and 1 neonatal death occurred. All cases of fetal hydrops and complete regression after birth were in the macrocystic and microcystic CPAM groups, respectively. Twenty‐four neonates (20.7%) had respiratory symptoms, and 18 (15.5%) required mechanical ventilation. Sixty‐three neonates (54.3%) underwent surgery, of whom 21 (33.3%) required surgery in the neonatal period. The maximum congenital pulmonary airway malformation volume ratio was significantly associated with all postnatal outcomes ( P < .05), and the optimal cutoff values were lower for respiratory symptoms, mechanical ventilation, and neonatal surgery in the macrocystic CPAMs. The maximum cyst size was also associated with all postnatal outcomes in macrocystic CPAMs ( P < .05). Conclusions: Different cutoff values for the maximum congenital pulmonary airway malformation volume ratio should be applied according to the CPAM type for the prediction of postnatal outcomes. The maximum cyst size can also be a useful prognostic factor in macrocystic CPAMs. Abstract : Access the CME test here and search by article title.