Increased EEG coherence in long‐distance and short‐distance connectivity in children with autism spectrum disorders. Issue 10 (19th August 2020)

• Record Type: Journal Article
• Authors: Wang, Jia; Wang, Xiaomin; Wang, Xuelai; Zhang, Huiying; Zhou, Yong; Chen, Lei; Li, Yutong; Wu, Lijie
• Is Part Of: Brain and behavior. Volume 10:Issue 10(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-08-19
• Subjects: autism spectrum disorder -- coherence -- electroencephalogram -- resting state; Neurology -- Periodicals; Neurosciences -- Periodicals; Psychology -- Periodicals; Psychiatry -- Periodicals; 616.8005
• DOI: 10.1002/brb3.1796
• Languages: English
• ISSNs: 2162-3279

Abstract

Abstract: Introduction: Autism spectrum disorder (ASD) is a complex and prevalent neurodevelopmental disorder characterized by deficits in social communication and social interaction as well as repetitive behaviors. Alterations in function connectivity are widely recognized in recent electroencephalogram (EEG) studies. However, most studies have not reached consistent conclusions, which could be due to the developmental nature and the heterogeneity of ASD. Methods: Here, EEG coherence analysis was used in a cohort of children with ASD ( n = 13) and matched typically developing controls (TD, n = 15) to examine the functional connectivity characteristics in long‐distance and short‐distance electrode pairs. Subsequently, we explore the association between the connectivity strength of coherence and symptom severity in children with ASD. Results: Compared with TD group, individuals with ASD showed increased coherence in short‐distance electrode pairs in the right temporal–parietal region (delta, alpha, beta bands), left temporal–parietal region (all frequency bands), occipital region (theta, alpha, beta bands), right central–parietal region (delta, alpha, beta bands), and the prefrontal region (only beta band). In the long‐distance coherence analysis, the ASD group showed increased coherence in bilateral frontal region, temporal region, parietal region, and frontal–occipital region in alpha and beta bands. The strength of such connections was associated with symptom severity. Discussion: Our study indicates that abnormal connectivity patterns in neuroelectrophysiology may be of critical importance to acknowledge the underlying brain mechanism. Abstract : Alterations in function connectivity are widely recognized in recent electroencephalogram (EEG) studies. Our study indicates that discovery of atypical brain coherence in ASD young children may be of a critical importance to acknowledge the underlying brain mechanism.