Squash cytology of a case of medulloblastoma with myogenic differentiation. Issue 11 (20th May 2020)

• Record Type: Journal Article
• Authors: Bhattacharya, Trishita; Bansal, Neha; De, Sayantan; Chatterjee, Uttara; Mallick, Mamata Guha
• Is Part Of: Diagnostic cytopathology. Volume 48:Issue 11(2020)
• Page Start: 1121
• Page End: 1124
• Publication Date: 2020-05-20
• Subjects: medulloblastoma -- medulloblastoma with myogenic differentiation -- squash cytology; Cytodiagnosis -- Periodicals; Pathology, Cellular -- Periodicals; Cytology -- Periodicals; 616.07582
• DOI: 10.1002/dc.24479
• Languages: English
• ISSNs: 8755-1039

Abstract

Abstract: Medulloblastoma with myogenic differentiation is not a distinct entity but a pattern of differentiation seen in <1% of medulloblastomas. Although squash cytology of medulloblastoma is well described, there are no reports available describing squash cytomorphology of this unusual variant of medulloblastoma. Intraoperative squash smears on a 2‐year‐old girl with a midline posterior fossa space occupying lesion revealed features of an embryonal tumor composed of small, round, and blue cells. In addition, it had several large, round, eosinophilic rhabomyoblasts, and a few strap cells scattered among the sea of small blue cells. Subsequent histology showed features of a medulloblastoma, classic type with myogenic differentiation. Molecular subtyping, based on immunohistochemistry alone, was in keeping with a non‐Wnt/non‐SHH activated type. Here we describe the squash cytomorphological details of a case of medulloblastoma with myogenic differentiation, along with its cytological differentials.