2-Activated 1, 3-enynes in enantioselective synthesis. Issue 40 (30th September 2020)

• Record Type: Journal Article
• Authors: Bao, Xiaoze; Ren, Jinhui; Yang, Yang; Ye, Xinyi; Wang, Baomin; Wang, Hong
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 40(2020)
• Page Start: 7977
• Page End: 7986
• Publication Date: 2020-09-30
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob01614d
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : 2-Activated 1, 3-enyne has emerged as a versatile synthetic precursor for the construction of valuable enantioenriched molecules. Abstract : The rapid enantioselective synthesis of valuable building blocks and pharmaceutically important compounds from easily accessible precursors is one of the major areas of focus in organic chemistry. In this context, 2-activated 1, 3-enyne has emerged as a powerful synthon in recent years for the efficient synthesis of enantioenriched furans, allenes, 4- H -pyrans, and 4-isoxazolines, which are privileged scaffolds in bioactive compounds and natural products. This review will cover the history of the development of 2-activated 1, 3-enyne in enantioselective synthesis along with the corresponding mechanisms, which may motivate further development in this area to forge more complex and valuable molecules.