Ethnic delineation of primary glioblastoma genome. (13th August 2020)

• Record Type: Journal Article
• Authors: Koo, Harim; Choi, Seung Won; Cho, Hee Jin; Lee, In‐Hee; Kong, Doo‐Sik; Seol, Ho Jun; Lee, Jung‐Il; Choi, Jung‐Won; Sa, Jason K.; Nam, Do‐Hyun
• Is Part Of: Cancer medicine. Volume 9:Number 19(2020)
• Page Start: 7352
• Page End: 7359
• Publication Date: 2020-08-13
• Subjects: ethnic -- genetics -- genomics -- glioblastoma; 616.994005
• DOI: 10.1002/cam4.3370
• Languages: English
• ISSNs: 2045-7634

Abstract

Abstract: Glioblastoma (GBM) is the most malignant primary brain tumor in adults with substantial genomic alterations. The median survival is approximately 14.6 months, despite aggressive therapeutic intervention, which comprised of surgical resection, radiotherapy, and chemotherapy. Recent studies on cancer genomic have revealed crucial insights into dynamic molecular subgroups within GBM, which govern distinct clinical response and sensitivity of each individual to therapy. In the present study, we analyzed genomic composition of primary GBMs between two ethnic groups [IRCR (Institute of Refractory Cancer Research), and TCGA (The Cancer Genome Atlats)] to explore genomic and molecular features that constitute malignant behavior of glioblastoma based on distinct ethnicity. We identified enrichments of MAPK and p53 pathways in IRCR patients, while aberrant activation of Receptor Tyrosine Kinases (RTKs) were predominant in TCGA cohort. We also discovered differential clinical prognosis between two groups and explored essential features that present such diversity. Abstract : Glioblastoma (GBM) is the most aggressive primary brain tumor. We analyzed recurrent somatic variants and molecular pathways that are enriched in different subpopulations.