COVID‐19 outbreak: The impact of stress on seizures in patients with epilepsy. (6th August 2020)

• Record Type: Journal Article
• Authors: Huang, Shanshan; Wu, Chunmei; Jia, Yuchao; Li, Guo; Zhu, Zhou; Lu, Kai; Yang, Yuyan; Wang, Furong; Zhu, Suiqiang
• Is Part Of: Epilepsia. Volume 61:issue 9(2020)
• Page Start: 1884
• Page End: 1893
• Publication Date: 2020-08-06
• Subjects: COVID‐19 -- epilepsy -- precipitant -- seizure exacerbation -- stress; Epilepsy -- Periodicals; 616.853
• DOI: 10.1111/epi.16635
• Languages: English
• ISSNs: 0013-9580

Abstract

Abstract: Objective: Stress is a known trigger for seizures in patients with epilepsy (PWE). However, the association between stress and seizures has not been thoroughly investigated. In December 2019, an outbreak of coronavirus disease (COVID‐19) occurred in Wuhan, Hubei province, China, causing tremendous collateral stress. This study was designed to evaluate the influence of the COVID‐19 outbreak on seizures in PWE in the most severely affected area, Wuhan, and its surrounding cities. Methods: In this single‐center, cross‐sectional study, PWE were surveyed via online questionnaires between February 23 and March 5, 2020. Collected data included demographic information, epilepsy‐related characteristics (seizure type, frequency, antiepileptic drugs [AEDs], and medication management), direct and perceived threat of COVID‐19, and changes in seizures during the outbreak. Psychological comorbidities were evaluated by the Patient Health Questionnaire–9, Generalized Anxiety Disorder–7 items, and Insomnia Severity Index (ISI). Multivariate logistic regression was used to identify precipitants for seizure exacerbation. Results: We received 362 completed questionnaires after excluding 12 duplicates (response rate = 63.51%). A total of 31 (8.56%) patients had increased seizures during the outbreak. Exposure history to COVID‐19 ( P = .001), uncontrolled seizure after AED therapy ( P = .020), seizure frequency of two or more times per month before the outbreak ( P = .005), change of AED regimen during the outbreak (AED reduction, withdrawal, replacement, skipping altogether; P = .002), and worry about the adverse effect of the outbreak on overall seizure‐related issues (severity = moderate to critical; P = .038) were risk factors for increased seizures. Significance: A minority of PWE experienced seizure exacerbation during the outbreak of COVID‐19. Stress, uncontrolled seizures, and inappropriate change in AED regimen were associated with increased seizures. Based on these findings, stress might be an independent precipitant for triggering seizures in some PWE.