Passenger lymphocyte thrombocytopenia due to human platelet antigen 3a antibodies: Case report and review of literature. Issue 10 (11th June 2020)

• Record Type: Journal Article
• Authors: French, Winnifred; Hopkins, Matthew; Poles, Anthony; Mijovic, Aleksandar
• Is Part Of: Transfusion. Volume 60:Issue 10(2020)
• Page Start: 2185
• Page End: 2188
• Publication Date: 2020-06-11
• Subjects: HPA‐3a antibodies -- liver transplantation -- passenger lymphocyte -- thrombocytopenia; Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; Blood Group Antigens -- Periodicals; Blood Preservation -- Periodicals; Blood Transfusion -- Periodicals; 615
• DOI: 10.1111/trf.15905
• Languages: English
• ISSNs: 0041-1132

Abstract

Abstract: We report a case of severe acute thrombocytopenia occurring within days after a cadaveric liver transplant, received from a female patient with aplastic anemia who died of intracranial bleeding. The donor, who was homozygous for the ITGA2B*002 (HPA‐3b) gene, had developed human platelet antigen (HPA)‐3a antibodies, whereas the recipient was homozygous for the ITGA2B*001 (HPA‐3a) gene. Thrombocytopenia responded to an infusion of immunoglobulin G. This is the first report of a passenger lymphocyte syndrome manifesting with thrombocytopenia due to anti‐HPA‐3a. We review the literature on thrombocytopenia in the setting of PLS and discuss the differential diagnosis.