Polyketides with quorum sensing inhibitory activity from the marine-derived fungus Aspergillus sp. ZF-79. Issue 11 (1st November 2020)

• Record Type: Journal Article
• Authors: Zhang, Fei; Kong, Fan-Dong; Ma, Qing-Yun; Xie, Qing-Yi; Zhou, Li-Man; Zhao, You-Xing; Guo, Lei
• Is Part Of: Journal of Asian natural products research. Volume 22:Issue 11(2020)
• Page Start: 999
• Page End: 1005
• Publication Date: 2020-11-01
• Subjects: Aspergillus sp. -- polyketides -- quorum sensing inhibitory activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2019.1670647
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Seven compounds were isolated from a marine-derived fungus Aspergillus sp. ZF-79, including three new polyketides (1 –3 ), named asperochrins D-F, along with four known compounds 4–7 . Their structures were determined on the basis of spectroscopic methods. All the compounds were tested for quorum sensing inhibitory (QSI) activity. Compounds 1, 3, 4, 5, and 6 exhibited QSI activity against Chromobacterium violaceum CV026 with MIC values of 50, 100, 50, 50, and 6.25 μM, respectively. Abstract :