Synthesis of novel chitosan-g-PNVCL nanofibers coated with gold-gold sulfide nanoparticles for controlled release of cisplatin and treatment of MCF-7 breast cancer. Issue 18 (11th December 2020)

• Record Type: Journal Article
• Authors: Banihashem, Solmaz; Nikpour Nezhati, Mahshid; Panahi, Homayon Ahmad; Shakeri-Zadeh, Ali
• Is Part Of: International journal of polymeric materials. Volume 69:Issue 18(2020)
• Page Start: 1197
• Page End: 1208
• Publication Date: 2020-12-11
• Subjects: Chitosan-g-PNVCL -- cisplatin -- gold-gold sulfide nanoparticles -- MCF-7 breast cancer -- nanofiber; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2019.1683557
• Languages: English
• ISSNs: 0091-4037

Abstract

Abstract: The chitosan-grafted-poly( N -vinylcaprolactam) copolymer was synthesized via the free radical polymerization and the electrospun nanofibers were prepared via electrospinning method. The nanofibers surface was coated with gold-gold sulfide nanoparticles and the cisplatin anticancer drug was loaded into the nanofibers for controlled release of cisplatin and the treatment of MCF-7 breast cancer cells. The synthesized gold nanoparticles were characterized using transmission electron microscopy, energy dispersive X-ray and ultraviolet–visible spectroscopy analysis. The characteristics of nanofibers were determined using Fourier-transform infrared spectroscopy, scanning electron microscope and dynamic light scattering analysis. The drug loading efficiency and cisplatin release profiles from synthesized nanofibers were evaluated. Graphical Abstract: