Patient Outcomes of Henoch–Schönlein Purpura Nephritis According to the New Semiquantitative Classification. (2nd September 2020)

• Record Type: Journal Article
• Authors: Yel, Sibel; Dursun, Ismail; Pinarbaşi, Ayşe Seda; Günay, Neslihan; Özdemir, Sümeyra; Şahin, Nihal; Akgün, Hülya; Ipekten, Funda; Poyrazoğlu, Hakan; Düşünsel, Ruhan
• Is Part Of: Fetal and pediatric pathology. Volume 39:Number 5(2020)
• Page Start: 381
• Page End: 389
• Publication Date: 2020-09-02
• Subjects: children -- glomerulonephritis -- histology -- renal biopsy -- semiquantitative -- vasculitis; Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.1080/15513815.2019.1658245
• Languages: English
• ISSNs: 1551-3815

Abstract

Abstract: Background: A new semiquantitative classification (SQC) for pediatric Henoch–Schönlein nephritis (HSN) was defined recently. The outcomes of pediatric HSN patients are reevaluated according to the new classification. Methods: Primary kidney biopsies from 80 HSN patients were scored using the new SQC. The International Study of Kidney Disease in Children (ISKDC) and SQC classifications were compared in terms of the patient outcomes. Outcomes were defined as: Outcome A ( n = 44) patients with no sign of renal disease, Outcome B ( n = 32) patients with minor urinary abnormalities, and Outcome C ( n = 4) patients with active renal disease. Results: The patients with outcome C had significantly higher biopsy scores and chronicity indices than patients in group A. There was no significant difference in areas under the curve between total biopsy SQC scores and ISKDC findings. Conclusions: Our results suggest that the modified SQC is not more sensitive than ISKDC classification for predicting the outcome in HSN cases.