Effects of Balanced Ultrafiltration During Extracorporeal Circulation for Children with Congenital Heart Disease on Postoperative Serum Inflammatory Response. (2nd September 2020)

• Record Type: Journal Article
• Authors: Chen, Feng; You, Yunpeng; Ding, Peicheng; Wu, Kaihong; Mo, Xuming
• Is Part Of: Fetal and pediatric pathology. Volume 39:Number 5(2020)
• Page Start: 401
• Page End: 408
• Publication Date: 2020-09-02
• Subjects: congenital heart disease -- inflammatory factor -- pulmonary function -- balanced ultrafiltration; Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.1080/15513815.2019.1661050
• Languages: English
• ISSNs: 1551-3815

Abstract

Abstract: Objectives: We studied inflammatory marker changes with ultrafiltration extracorporeal techniques and compared these levels to those occurring during conventional techniques. Methods: Seventy-four children undergoing extracorporeal circulation during congenital heart surgery were divided into two groups—conventional (control) and balanced ultrafiltrations (study). Serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and soluble intercellular adhesion molecule-1 (sICAM-1), static lung compliance (Cstat), alveolar-arterial oxygen partial pressure difference (A-aDO2), and oxygenation index (OI) were measured. Results: Thirty minutes after extracorporeal circulation (T1), IL-6 and TNF-α levels significantly increased ( p < .05), which plummeted 3 h after surgery (T2). The levels in the study group were lower ( p < .05). sICAM-1 levels at T1 and T2 significantly exceeded those at T0, and study group had lower levels ( p < .05). At T1, Cstat and OI dropped ( p < .05), which increased at T2 ( p < .05), and study group had less decreases ( p < .05). A-aDO2 at T1 surpassed that before intervention ( p < .05), and study group had less increase ( p < .05). Conclusion: Balanced ultrafiltration exerts protective effects on children with congenital heart disease undergoing extracorporeal circulation.