Al(iii)-NTA-fluoride: a simple model system for Al–F binding with interesting thermodynamics. Issue 39 (30th September 2020)

• Record Type: Journal Article
• Authors: Hacaperková, Eliška; Jaroš, Adam; Kotek, Jan; Notni, Johannes; Straka, Michal; Kubíček, Vojtěch; Hermann, Petr
• Is Part Of: Dalton transactions. Volume 49:Issue 39(2020)
• Page Start: 13726
• Page End: 13736
• Publication Date: 2020-09-30
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/d0dt02644a
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : Unsaturated Al III complex shows a fast exchange of water molecules, hydroxide and fluoride anions in the coordination sphere, highly pH-dependent fluoride binding and release of fluorides at high pH or at high phosphate anion concentrations. Abstract : Al(iii ) complexes are extensively studied as [ 18 F]fluoride carriers in positron emission tomography. However, our limited knowledge on their thermodynamic and kinetic properties has hindered efforts to easily prepare radiochemically pure compounds while simultaneously reducing the overall labeling time. Thus, to improve our understanding of fluoride binding to coordinatively unsaturated Al(iii ) complexes, we investigated the ternary system Al(iii )–H3 NTA–F − (H3 NTA = nitrilo-triacetic acid) by NMR, potentiometry and X-ray diffraction. Our results show that the [Al(NTA)] complex binds two water molecules, which are replaced by fluorides. Individual species and isomers show separate 19 F NMR signals and different stability constants. The two available positions on the [Al(NTA)] complex feature significantly different properties in terms of basicity of the coordinated water molecules and preferential binding of fluoride anions. Fluorides are effectively bound in weakly acidic or neutral solutions, whereas hydroxido species are preferentially formed in alkaline solutions. Our experimental observations were rationalized by theoretical calculations: predictions of the energy ordering of complexes and isomers, interpretation of 19 F NMR chemical shifts, and natural bonding orbital analysis. Radiolabeling of [Al(NTA)] with [ 18 F]fluoride gave low yields that confirmed a high affinity of the complex for hydroxide anions.