A fluorescent target-guided Paal–Knorr reaction. Issue 61 (7th October 2020)
- Record Type:
- Journal Article
- Title:
- A fluorescent target-guided Paal–Knorr reaction. Issue 61 (7th October 2020)
- Main Title:
- A fluorescent target-guided Paal–Knorr reaction
- Authors:
- Wagh, Sachin B.
Maslivetc, Vladimir
La Clair, James J.
Kornienko, Alexander - Abstract:
- Abstract : A pocket-templated Paal–Knorr reaction delivers fluorescent COX-2 probes. Abstract : It has become increasingly apparent that high-diversity chemical reactions play a significant role in the discovery of bioactive small molecules. Here, we describe an expanse of this paradigm, combining a 'target-guided synthesis' concept with Paal–Knorr chemistry applied to the preparation of fluorescent ligands for human prostaglandin-endoperoxide synthase (COX-2).
- Is Part Of:
- RSC advances. Volume 10:Issue 61(2020)
- Journal:
- RSC advances
- Issue:
- Volume 10:Issue 61(2020)
- Issue Display:
- Volume 10, Issue 61 (2020)
- Year:
- 2020
- Volume:
- 10
- Issue:
- 61
- Issue Sort Value:
- 2020-0010-0061-0000
- Page Start:
- 37035
- Page End:
- 37039
- Publication Date:
- 2020-10-07
- Subjects:
- Chemistry -- Periodicals
540.5 - Journal URLs:
- http://pubs.rsc.org/en/Journals/JournalIssues/RA ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d0ra06962k ↗
- Languages:
- English
- ISSNs:
- 2046-2069
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8036.750300
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 14418.xml