Insight into hydroxyl radical-mediated cleavage of caged methylene blue: the role of Fenton's catalyst for antimalarial hybrid drug activation. Issue 80 (9th September 2020)

• Record Type: Journal Article
• Authors: Dao, Huy Minh; Husain, Islam; Shankar, Vijay Kumar; Khan, Shabana I.; Murthy, S. Narasimha; Jo, Seongbong
• Is Part Of: Chemical communications. Volume 56:Issue 80(2020)
• Page Start: 12017
• Page End: 12020
• Publication Date: 2020-09-09
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc05204c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Probed by this platform, hemoproteins were demonstrated to be a much more efficient Fenton's catalyst than commonly used inorganic Fe(ii ) salts. Abstract : Methylene blue with a 10-N carbamoyl linkage was reported to be a hydroxyl radical triggered cleavable ligand. Probed by this platform, hemoproteins were demonstrated to be a much more efficient Fenton's catalyst than commonly used inorganic Fe(ii ) salts. The applicability of this ligand was demonstrated through the capability of being triggered by elevated reactive oxygen species levels at diseased tissue, with malaria-parasitized erythrocytes as an in vitro model.