Immunogenic exosome-encapsulated black phosphorus nanoparticles as an effective anticancer photo-nanovaccine. Issue 38 (29th September 2020)

• Record Type: Journal Article
• Authors: Liu, Quan; Fan, Taojian; Zheng, Yuanyuan; Yang, Sheng-li; Yu, Zhiqiang; Duo, Yanhong; Zhang, Yuhua; Adah, Dickson; Shi, Lulin; Sun, Zhe; Wang, Dou; Xie, Jianlei; Wu, Hong; Wu, Zongze; Ge, Chenchen; Qiao, Lijun; Wei, Chaoying; Huang, Luodan; Yan, Qiaoting; Yang, Qinhe; Bao, Shiyun; Liu, Li-Ping; Zhang, Han
• Is Part Of: Nanoscale. Volume 12:Issue 38(2020)
• Page Start: 19939
• Page End: 19952
• Publication Date: 2020-09-29
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/d0nr05953f
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Exosome-encapsulated black phosphorus nanoparticles as an innovative photo-nanovaccine against cancers. Abstract : Tumor vaccines are a promising form of cancer immunotherapy, but difficulties such as neo-antigen identification, activation of immune cells, and tumor infiltration prevent their clinical breakthrough. Interestingly, nanotechnology-based photothermal therapy (PTT) has great potential to overcome these barriers. Previous studies have shown that serum exosomes (hEX) from hyperthermia-treated tumor-bearing mice displayed an array of patient-specific tumor-associated antigens (TAAs), and strong immunoregulatory abilities in promoting dendritic cell (DC) differentiation and maturation. Here, we developed a tumor vaccine (hEX@BP) by encapsulating black phosphorus quantum dots (BPQDs) with exosomes (hEX) against a murine subcutaneous lung cancer model. In comparison with BPQDs alone (BP), hEX@BP demonstrated better long-term PTT performance, greater elevation of tumor temperature and tumor targeting efficacy in vivo . Vaccination with hEX@BP in combination with PTT further demonstrated an outstanding therapeutic efficacy against established lung cancer, and promoted the infiltration of T lymphocytes into the tumor tissue. Our findings demonstrated that hEX@BP might be an innovative cancer photo-nanovaccine that offers effective immuno-PTT against cancers.