3D printed high-resolution scaffold with hydrogel microfibers for providing excellent biocompatibility. (January 2021)

• Record Type: Journal Article
• Authors: Ye, Wenjie; Xie, Chaoqi; Liu, Yande; He, Yong; Gao, Qing; Ouyang, Aiguo
• Is Part Of: Journal of biomaterials applications. Volume 35:Number 6(2021)
• Page Start: 633
• Page End: 642
• Publication Date: 2021-01
• Subjects: Melt electrowriting -- electrospinning -- gelatin methacrylate -- composite scaffold; Biomedical engineering -- Periodicals; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1177/0885328220962606
• Languages: English
• ISSNs: 0885-3282

Abstract

Melt electrowriting (MEW) can print high-resolution scaffolds with the ultrafine fibers from 800 nm to 20 µm. However, the cell seeding efficiency relatively low due to the large pore size of the MEW scaffold. Here, we reported a method to solve this dilemma by electrospinning a gelatin methacrylate (GelMA) hydrogel fibers membrane (HFM) on the MEW scaffold. This composite scaffold can own the controlled structures and porosity and excellent cell seeding performance. We systematically investigate the fabrication, morphology, and biocompatibility of composite scaffolds. The implanting of human umbilical vein endothelial cells(HUVES) showed excellent adhesion and biocompatibility on the composite scaffold. Moreover, the cells migrated gradually into the MEW scaffold along the GelMA HFM to form the cell sheet. We hold the opinion that the composite scaffolds have potential applications in the field of tissue engineering repair.