A new hydrophilic biodegradable ureteral stent restrain encrustation both in vitro and in vivo. (January 2021)

• Record Type: Journal Article
• Authors: Zhang, Yu; He, Jian; Chen, Hechun; Xiong, Chengdong
• Is Part Of: Journal of biomaterials applications. Volume 35:Number 6(2021)
• Page Start: 720
• Page End: 731
• Publication Date: 2021-01
• Subjects: Ureteral stents -- degradation -- hydrophilicity -- encrustation -- surface morphology; Biomedical engineering -- Periodicals; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1177/0885328220949376
• Languages: English
• ISSNs: 0885-3282

Abstract

Ureteral stents have been widely used as biomedical devices to treat some urological diseases for several decades. However, the encrustation complications hamper the long-time clinical use of the ureteral stents. In this work, a new type of biodegradable material for the ureteral stents, methoxypoly(ethylene glycol)-block-poly(L-lactide-ran-Ɛ-caprolactone) (mPEG-PLACL), is evaluated to overcome this problem. The results show that the hydrophilicity and degradation rate in artificial urine of mPEG-PLACL are both significantly increased. It is worth noting that the mPEG-PLACL shows a lower amount of encrustation after immersing the stents in the dynamic urinary extracorporeal circulation (DUEC) model for 7 days. In addition, 71% Ca and 92% Mg are inhibited in vivo by quantitative analysis. Pathological analysis exhibit that the mPEG-PLACL cause less diffuse mucosal hyperplasia after 7 weeks of implantation. All the results indicate that this new type of biodegradable material had an excellent potential for the ureteral stents in the future.