Molecular Advances and Targeted Therapies for Pediatric Central Nervous System Tumors. (January 2021)

• Record Type: Journal Article
• Authors: Gordon, Danielle; Maria, Bernard L.
• Is Part Of: Journal of child neurology. Volume 36:Number 1(2021)
• Page Start: 5
• Page End: 29
• Publication Date: 2021-01
• Subjects: pediatric brain tumors -- neurogenetics -- molecular pathogenesis -- therapies -- medulloblastoma -- cognitive effects -- ependymoma; Nervous system -- Diseases -- Periodicals; 618.928
• DOI: 10.1177/0883073820946892
• Languages: English
• ISSNs: 0883-0738

Abstract

Central nervous system tumors are extremely rare in the pediatric population and molecularly heterogeneous. Growing scientific research and clinical practice experience are improving medical therapies to increase survival outcomes and quality of life and reduce side effects. The 2019 Neurobiology of Disease in Children Symposium, held in conjunction with the 48th annual meeting of the Child Neurology Society, aimed to (1) describe molecular advances in tumor classification, (2) better understand the evolution of targeted therapies, and (3) more clearly formulate a treatment plan for patients. The article summarizes the presentations and includes an edited transcript of a panel discussion.