Unveiling the high reactivity of strained dibenzocyclooctyne in [3 + 2] cycloaddition reactions with diazoalkanes through the molecular electron density theory. (16th July 2020)

• Record Type: Journal Article
• Authors: Domingo, Luis R.; Acharjee, Nivedita
• Is Part Of: Journal of physical organic chemistry. Volume 33:Number 11(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-07-16
• Subjects: [3 + 2] cycloadditions -- diazoalkanes -- dibenzocyclooctyne -- molecular electron density theory -- molecular reactivity -- strained molecules; Chemistry, Physical organic -- Periodicals; 547.1
• DOI: 10.1002/poc.4100
• Languages: English
• ISSNs: 0894-3230

Abstract

Abstract: The strain‐promoted [3 + 2] cycloaddition (SP‐32CA) reactions of two diazoalkanes with strained dibenzocyclooctyne (DIBO) have been studied within the molecular electron density theory. Analysis of the electron localisation function of diazoalkanes allows characterising their pseudoradical structures. These pmr‐type 32CA reactions, which follow a one‐step mechanism with high asynchronicity and some polar character, have lower activation enthalpies, 11.4 and 15.4 kcal mol −1, than those with acetylene, 19.7 and 23.1 kcal mol −1, in agreement with the experimental outcomes. Analysis of the changes in electron density along the SP‐32CA reaction of phenyldiazomethane with DIBO indicates that the strain favours the depopulation of the C–C triple bond of DIBO, reducing the activation energy. Abstract : The strain‐promoted [3 + 2] cycloaddition reactions of two pseudoradical diazoalkanes with strained dibenzocyclooctyne have been studied within the molecular electron density theory. The reactions follow a one‐step mechanism with high asynchronicity and some polar character. The strain favours the depopulation of the C–C triple bond, reducing the activation energies by approximately 8 kcal mol −1 .