Anatomy of brain lesions after stroke predicts effectiveness of mirror therapy. (25th February 2020)

• Record Type: Journal Article
• Authors: Hamzei, Farsin; Erath, Gabriele; Kücking, Ursula; Weiller, Cornelius; Rijntjes, Michel
• Is Part Of: European journal of neuroscience. Volume 52:Number 6(2020)
• Page Start: 3628
• Page End: 3641
• Publication Date: 2020-02-25
• Subjects: brain plasticity -- dual loop model -- fMRI -- mirror therapy -- stroke rehabilitation; Nervous system -- Periodicals; 612.8
• DOI: 10.1111/ejn.14698
• Languages: English
• ISSNs: 0953-816X

Abstract

Abstract: To improve clinical outcome, one longstanding goal in treating stroke patients has been an individual therapy based on functional and anatomical knowledge of the single patient. Therefore, in this study brain imaging of 36 chronic stroke patients was analyzed to identify parameters predicting clinical recovery. T1‐weighted MRI was acquired to assess the lesion; functional MRI was used to visualize existing resources; DTI for the integrity of the corticospinal tract (CST) and long association tracts. These data were related to the clinical course. All patients were treated intensively with the mirror therapy (MT) only. After the training period, we analyzed which patient's feature would predict a beneficial course. Patients as a group improved after MT, but according to the fMRI activation of primary sensorimotor cortex (SMC), they could be divided in two groups with very diverging clinical outcome: those with ipsilesional SMC activation showed a noticeable increase of clinical scores, accompanied with ipsilesional activation in the frontal projection areas of the dorsal and ventral streams during action observation in fMRI. Those with contralesional SMC activation had lesions affecting both the dorsal and ventral stream and did not benefit from MT. The outcome for this therapy was not related to affection of CST. This study demonstrates that only in patients in which dorsal and ventral streams are not affected and therefore an interaction between these streams in post‐ and prerolandic regions is possible, MT can induce clinical improvement. Consequently, knowledge of the anatomical lesion can predict the beneficial course of MT. Abstract : After stroke, the goal is to find the optimal therapeutic approach of the individual patient. We applied mirror therapy (MT) to stroke patients in order to analyze a predictive value based on functional and anatomical status. Considering all applied methods (clinical test, fMRI, DTI, lesion analysis), patients with a certain lesion pattern do not benefit from MT. It this is known in advance, a predictive statement for the effectiveness of MT can be made.