Surface modification of multiwalled carbon nanotubes via surface RAFT copolymerization method and capecitabine-loaded anticancer hydrogel for controlled drug delivery in stomach. Issue 16 (1st November 2020)

• Record Type: Journal Article
• Authors: Hosseinzadeh, Alireza; Pashaei, Shahryar; Hosseinzadeh, Soleyman; Namazi, Hassan
• Is Part Of: Polymer-plastics technology and materials. Volume 59:Issue 16(2020)
• Page Start: 1812
• Page End: 1821
• Publication Date: 2020-11-01
• Subjects: RAFT polymerization -- drug-delivery system -- controlled polymerization -- anticancer; Polymers -- Periodicals; Polymerization -- Periodicals; Plastics -- Periodicals; Plastics; Polymerization; Polymers; Periodicals; 668
• DOI: 10.1080/25740881.2020.1765387
• Languages: English
• ISSNs: 2574-0881

Abstract

ABSTRACT: In our work, reversible addition-fragmentation chain transfer (RAFT)/carbon nanotube (CNT)/acrylic acid (AA)/acrylamide (AAm) nanocomposite was synthesized by living radical polymerization. The structure and surface morphology of the synthesized RAFT-CNT-Hydrogel nanocomposites were analyzed by FTIR, 1 HNMR, SEM, TEM, XRD, and TGA/DTG techniques. The results indicated that PAA/AAm chains grafted with CNT by RAFT polymerization. RAFT-CNT-Hydrogel nanocomposites for drug release investigated in different buffers resulted in a strong pH-sensitive behavior. In total, the obtained hydrogel drug-delivery systems are presented a proper effect versus stomach cancer in vitro and in vivo, and it can be used as candidates for controlled release of anticancer drugs in stomach with exalted remedial agents. GRAPHICAL ABSTRACT: Schematic representation of RAFT-CNT-Hydrogel in drug-delivery system