Family history of diabetes mellitus and long-term endocrine morbidity of the offspring. (2nd October 2020)

• Record Type: Journal Article
• Authors: Alon, Yuval; Wainstock, Tamar; Sheiner, Eyal; Pariente, Gali
• Is Part Of: Gynecological endocrinology. Volume 36:Number 10(2020)
• Page Start: 869
• Page End: 872
• Publication Date: 2020-10-02
• Subjects: Obesity -- diabetes -- endocrine morbidity -- family history -- screening; Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.1080/09513590.2020.1725971
• Languages: English
• ISSNs: 0951-3590

Abstract

Abstract: Background: Little is known regarding the long-term outcomes of offsprings to non-diabetic mothers with family history of diabetes mellitus (FHDM). Objective: The aim of the study was to determine whether being born to a non-diabetic mother with FHDM increases the risk for long-term endocrine morbidity. Methods: This is a population-based cohort study, comparing long-term endocrine morbidity between offspring born to non-diabetic mothers with and without FHDM. The Kaplan–Meier survival curve was used to compare cumulative morbidity incidence. Cox proportional hazards model was performed to control for confounders. Results: During the study period, 208, 728 children met the inclusion criteria. Using a Kaplan–Meier survival curve, offspring born to non-diabetic mothers with a FHDM had higher cumulative incidence of endocrine morbidity compared to their counterparts without FHDM (Log rank test p = .014). Using a Cox model, controlling for confounders, being born to a non-diabetic mother with FHDM was an independent risk factor for long-term endocrine morbidity of the offspring (adjusted HR = 1.24, 95%CI 1.001–1.54; p = .043). Conclusion: Being born to a non-diabetic mother with a FHDM is independently associated with higher risk for long-term endocrine morbidity of the offspring.