Two Thalamic Regions Screened Using Laser Capture Microdissection with Whole Human Genome Microarray in Schizophrenia Postmortem Samples. (1st June 2020)

• Record Type: Journal Article
• Authors: Bakshi, Kalindi; Kemether, Eileen M.
• Other Names: Schnack Hugo Academic Editor.
• Is Part Of: Schizophrenia research and treatment. Volume 2020(2020)
• Publication Date: 2020-06-01
• Subjects: Schizophrenia -- Periodicals; Schizophrenia; Schizophrenia; Electronic journals; Periodicals; Periodicals; 616.898
• DOI: 10.1155/2020/5176834
• Languages: English
• ISSNs: 2090-2085

Abstract

Abstract : We used whole human genome microarray screening of highly enriched neuronal populations from two thalamic regions in postmortem samples from subjects with schizophrenia and controls to identify brain region-specific gene expression changes and possible transcriptional targets. The thalamic anterior nucleus is reciprocally connected to anterior cingulate, a schizophrenia-affected cortical region, and is also thought to be schizophrenia affected; the other thalamic region is not. Using two regions in the same subject to identify disease-relevant gene expression differences was novel and reduced intersubject heterogeneity of findings. We found gene expression differences related to miRNA-137 and other SZ-associated microRNAs, ELAVL1, BDNF, DISC-1, MECP2 and YWHAG associated findings, synapses, and receptors. Manual curation of our data may support transcription repression.