Distribution and Prognostic Significance of Estrogen Receptor α (ERα), Estrogen Receptor β (ERβ), and Human Epidermal Growth Factor Receptor 2 (HER-2) in Thyroid Carcinoma. (5th May 2020)

• Record Type: Journal Article
• Authors: Mishra, Anjali; Kumari, Niraj; Jha, Chandan Kumar; Bichoo, Raouef Ahamed; Mishra, Shravan Kumar; Krishnani, Narendra; Mishra, Saroj Kanta
• Other Names: Stack Brendan C. Academic Editor.
• Is Part Of: Journal of thyroid research. Volume 2020(2020)
• Publication Date: 2020-05-05
• Subjects: Thyroid gland -- Cancer -- Periodicals; Thyroid gland -- Diseases -- Periodicals; 616.99444
• DOI: 10.1155/2020/6935724
• Languages: English
• ISSNs: 2090-8067

Abstract

Abstract : Purpose . The primary aim of this study was to determine the incidence of estrogen receptor α (ER α ), estrogen receptor β (ER β ), and human epidermal growth factor receptor 2 (HER-2) expression in various subtypes of thyroid carcinoma (TC) of follicular origin and the secondary aim was to correlate the expression with various clinicopathologic prognostic factors. Methods . Immunohistochemistry analysis was performed on archival paraffin-embedded tissue sections (1991–2016). ER α, ER β, and HER-2 expressions were correlated with clinicopathologic prognostic factors, disease recurrence, and overall survival (OS). Results . A total of 264 TC patients were included in the study. Incidences of ER α, ER β, and HER-2 were 8.1 vs 16.3 vs 13.9% p = 0.15, 26.6 vs 11.5 vs 36.1% p = 0.002, and 12.9 vs 2.9 vs 0% p = 0.003 in papillary thyroid carcinoma (PTC), follicular thyroid carcinoma (FTC), and poorly differentiated thyroid carcinoma (PDTC), respectively. Overall ER α had significant correlation with distant metastases (0.038) and in case of PDTC with multicentricity p = 0.037 . ER β had significant correlation with lymph node metastases p = 0.023 in FTC. HER-2 correlated with tumor size p = 0.027 only on univariate analysis. OS did not correlate with expression of any receptor. Conclusion . ER α, ER β, and HER-2 have differential expression and prognostic implications in different TC subtypes.