G-quadruplex-proximity protein labeling based on peroxidase activity. Issue 78 (1st September 2020)

• Record Type: Journal Article
• Authors: Masuzawa, Tatsuki; Sato, Shinichi; Niwa, Tatsuya; Taguchi, Hideki; Nakamura, Hiroyuki; Oyoshi, Takanori
• Is Part Of: Chemical communications. Volume 56:Issue 78(2020)
• Page Start: 11641
• Page End: 11644
• Publication Date: 2020-09-01
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc02571b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : G-quadruplex-proximity protein labeling was performed using a hemin-parallel G-quadruplex (G4) complex. A tyrosine labeling reaction was accelerated in close proximity to the hemin with enhanced peroxidase activity by binding to parallel G4. Abstract : Peroxidase-proximity protein labeling was performed using a hemin-parallel G-quadruplex (G4) complex. A tyrosine labeling reaction using an N -methyl luminol derivative was accelerated in close proximity to the hemin with enhanced peroxidase activity by binding to parallel G4. The TERRA–hemin complex activated the labeling of many RNA-binding proteins, including heterogeneous nuclear ribonucleoproteins, in a HeLa cell lysate.