Next-generation androgen receptor inhibitors in non-metastatic castration-resistant prostate cancer. (December 2020)

• Record Type: Journal Article
• Authors: Lavaud, Pernelle; Dumont, Clément; Thibault, Constance; Albiges, Laurence; Baciarello, Giulia; Colomba, Emeline; Flippot, Ronan; Fuerea, Alina; Loriot, Yohann; Fizazi, Karim
• Is Part Of: Therapeutic advances in medical oncology. Volume 12(2020)
• Publication Date: 2020-12
• Subjects: apalutamide -- castration resistance -- darolutamide -- enzalutamide -- next generation androgen receptor inhibitors -- non-metastatic setting -- prostate cancer; Oncology -- Periodicals; Cancer -- Treatment -- Periodicals; 616.994005
• DOI: 10.1177/1758835920978134
• Languages: English
• ISSNs: 1758-8340

Abstract

Until recently, continuing androgen deprivation therapy (ADT) and closely monitoring patients until evolution towards metastatic castration-resistant prostate cancer (CRPC) were recommended in men with non-metastatic CRPC (nmCRPC). Because delaying the development of metastases and symptoms in these patients is a major issue, several trials have investigated next-generation androgen receptor (AR) axis inhibitors such as apalutamide, darolutamide, and enzalutamide in this setting. This review summarizes the recent advances in the management of nmCRPC, highlighting the favourable impact of next-generation AR inhibitors on metastases-free survival, overall survival and other clinically meaningful endpoints.