Morphometric analysis of alpha-1, 3-galactosyltransferase knockout pig kidney and heart. (December 2020)

• Record Type: Journal Article
• Authors: Vasamsetti, Bala Murali Krishna; Park, Sang Hyoun; Rallabandi, Harikrishna Reddy; Lee, Heasun; Byun, Sung-June; Ock, Sun A; Lee, Hwi-Cheul; Hwang, Seongsoo; Oh, Keon Bong
• Is Part Of: Laboratory animals. Volume 54:Number 6(2020)
• Page Start: 599
• Page End: 604
• Publication Date: 2020-12
• Subjects: Alpha-1 -- 3-galactosyltransferase knockout pig -- morphometries -- xenotransplantation; Animal experimentation -- Periodicals; Animal models in research -- Periodicals; Laboratory animals -- Periodicals; Animal welfare -- Periodicals; 636.0885
• DOI: 10.1177/0023677220915218
• Languages: English
• ISSNs: 0023-6772

Abstract

We report a morphometric evaluation of α1, 3-galactosyltransferase knockout (GTKO) pig heart and kidney ( n = 9) at the end of one, three and seven months. Organs parameters gradually increased with the age ( p < 0.05) and body weight ( p < 0.05) of the pigs. Organs morphometries were significantly correlated to the age and body weight of the animal. We were able to conclude the average size of GTKO pig heart and kidney based on age and body weight, which could be helpful in estimating the size of these organs non-invasively for transplantation.