Correlation of Serum Cardiac Markers with Acute Decompensating Events in Liver Cirrhosis. (24th September 2020)

• Record Type: Journal Article
• Authors: Li, Miaomiao; Guo, Zeqi; Zhang, Dan; Xu, Xiangbo; Romeiro, Fernando Gomes; Mancuso, Andrea; Zhang, Jingqiao; Feng, Ruirui; Zhou, Xinmiao; Hong, Cen; Qi, Xingshun
• Other Names: Funel Niccola Academic Editor.
• Is Part Of: Gastroenterology research and practice. Volume 2020(2020)
• Publication Date: 2020-09-24
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; 616.33005
• DOI: 10.1155/2020/4019289
• Languages: English
• ISSNs: 1687-6121

Abstract

Abstract : Background and Aim . Liver cirrhosis is often accompanied by insidious cardiac dysfunction. This retrospective cross-sectional study is aimed at exploring the correlation between serum cardiac markers and decompensating events in liver cirrhosis. Methods . Cirrhotic patients who were consecutively hospitalized between January 2016 and March 2019 were screened. Serum cardiac biomarkers at admission, including N-Terminal pro-B-type natriuretic peptide (NT-pro BNP), high-sensitivity cardiac troponin T (hs-cTnT), creatine kinase (CK), creatine kinase MB (CK-MB), and lactate dehydrogenase (LDH), were collected. Acute decompensating events at admission, primarily including ascites, acute gastrointestinal hemorrhage, and acute-on-chronic liver failure (ACLF), were recorded. Results . The NT-pro BNP level was significantly higher in cirrhotic patients with acute decompensating events than in those without any decompensating events (median: 140.75 pg/mL versus 41.86 pg/mL, P < 0.001 ). The NT-pro BNP level significantly correlated with ascites, acute gastrointestinal hemorrhage, and ACLF. The hs-cTnT level was significantly higher in cirrhotic patients with acute decompensating events than in those without decompensating events (median: 0.008 ng/mL versus 0.006 ng/mL, P = 0.007 ). The hs-cTnT level significantly correlated with acute gastrointestinal hemorrhage, but not ascites or ACLF. LDH (185.0 U/L versus 173.5 U/L, P = 0.281 ), CK (71 U/L versus 84 U/L, P = 0.157 ), and CK-MB (29.5 U/L versus 33.0 U/L, P = 0.604 ) levels were not significantly different between cirrhotic patients with and without acute decompensating events. Conclusion . The elevated NT-pro BNP level seems to be closely related to the development of acute decompensating events in liver cirrhosis.