Gastritis Stages in Monozygotic and Dizygotic Dyspeptic Twins. (2nd July 2020)

• Record Type: Journal Article
• Authors: Urba, Mindaugas; Skieceviciene, Jurgita; Janciauskas, Dainius; Jonaitis, Laimas; Kupcinskas, Limas; Fassan, Matteo; Rugge, Massimo; Kupcinskas, Juozas
• Other Names: Annibale Bruno Academic Editor.
• Is Part Of: Gastroenterology research and practice. Volume 2020(2020)
• Publication Date: 2020-07-02
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; 616.33005
• DOI: 10.1155/2020/9510717
• Languages: English
• ISSNs: 1687-6121

Abstract

Abstract : Background . The progression of Helicobacter pylori -associated gastritis towards atrophic gastritis is modulated by host-related and environmental factors. Studies that explore the possible involvement of host-related versus environmental factors in the development of gastritis phenotype induced by H. pylori are highly needed. Aims . Our study was aimed at investigating the phenotype of H. pylori -associated gastritis in two cohorts of monozygotic and dizygotic twins, using the OLGA/OLGIM gastritis staging system. Methods . Two cohorts of monozygotic (14 pairs) and dizygotic (15 pairs) dyspeptic twins prospectively underwent endoscopy with biopsy sampling based on Sydney protocol. H. pylori status and OLGA/OLGIM stages were assessed and compared. Results . The mean age of monozygotic and dizygotic twins was 40.4 and 38.6 years, respectively (p = 0.623 ). The overall prevalence of H. pylori infection was 51.7%. Among the 14 monozygotic twin pairs, five pairs were H. pylori -positive, four were H. pylori -negative, and five were H. pylori -discordant. Among the 15 dizygotic twin pairs, five pairs were H. pylori -positive, five were H. pylori -negative, and five were H. pylori -discordant. Concordance for antrum atrophy in monozygotic twins was 78.6% (11/14 pairs) and in dizygotic twins 73.3% (11/15 pairs) (p = 0.742 ). Concordance for corpus atrophy in monozygotic versus dizygotic twins was 92.9% (13/14 pairs) and 86.7% (13/15 pairs), respectively (p = 0.584 ). Concordance for antrum intestinal metaplasia (IM) in monozygotic twins was 85.7% (12/14 pairs) and in dizygotic 73.3% (11/15 pairs) (p = 0.411 ). Concordance for corpus IM in monozygotic twins was 85.7% (12/14 pairs) and in dizygotic 86.7% (13/15 pairs) (p = 0.941 ). Among monozygotic and dizygotic subjects, the stage of gastritis was concordant in both H. pylori -positive and H. pylori -negative subjects. Conclusions . In conclusion, histological gastric mucosa alterations in monozygotic and dizygotic twins showed high rates of concordance. Furthermore, OLGA/OLGIM gastritis stages were not modulated by the zygosity of the twins.