Transabdominal approach for renal cell carcinoma with supradiaphragmatic tumor thrombus: description of a modified technique and indications for treatment. Issue 11 (November 2020)

• Record Type: Journal Article
• Authors: Wang, Guoliang; Bi, Hai; Ye, Jianfei; Zhang, Hongxian; Hou, Xiaofei; Liu, Cheng; Qiu, Min; Tian, Yu; Kaushik, Dharam; Ma, Lulin
• Is Part Of: Journal of international medical research. Volume 48:Issue 11(2020)
• Publication Date: 2020-11
• Subjects: Renal cell carcinoma -- supradiaphragmatic tumor thrombus -- transabdominal approach -- modified technique -- inferior vena cava -- nephrectomy; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/0300060520962288
• Languages: English
• ISSNs: 0300-0605

Abstract

Objective: We investigated the safety and effectiveness of a modified transabdominal approach for renal cell carcinoma (RCC) with a supradiaphragmatic inferior vena cava (IVC) tumor thrombus (TT). Methods: Eight patients underwent radical nephrectomy with removal of a supradiaphragmatic IVC-TT through an abdominal incision using a transdiaphragmatic approach in Peking University Third Hospital from April 2015 to January 2018. We modified this technique using a Foley catheter balloon to avoid piggyback liver mobilization. Results: All patients underwent successful operations. The median operative time was 7 hours 23 minutes. The median estimated blood loss was 2963 mL. All patients received a blood transfusion with a median blood infusion volume of 2162 mL. Two patients with Budd–Chiari syndrome developed postoperative ascites and hydrothorax due to non-watertight repair of the diaphragm. During a follow-up of 11 to 44 months, only one patient died of liver metastasis and four patients developed distant metastasis without recurrence in the IVC. Conclusions: The modified transabdominal approach described herein has an encouraging safety profile and provides a surgical option for treatment of RCC with a supradiaphragmatic IVC-TT. More evidence concerning the beneficial role of this procedure will be elucidated in further studies.