Bilateral Basal Ganglion Hemorrhage after Severe Olanzapine Intoxication. (1st September 2020)

• Record Type: Journal Article
• Authors: Schweyer, Kerstin; Fatke, Bastian; Kreiser, Kornelia; Rabe, Christian; Seifert, Christian; Ikenberg, Benno
• Other Names: Inada Toshiya Academic Editor.
• Is Part Of: Case reports in psychiatry. Volume 2020(2020)
• Publication Date: 2020-09-01
• Subjects: Psychiatry -- Periodicals; Psychiatry -- Case studies -- Periodicals; Mental Disorders; Psychiatry; Psychiatry; Periodicals; Case studies; Periodicals; 616.89
• DOI: 10.1155/2020/2398721
• Languages: English
• ISSNs: 2090-682X

Abstract

Abstract : Olanzapine is a second-generation antipsychotic drug which is generally considered safe with well therapeutic antipsychotic effects. We describe a patient suffering from bilateral intracerebral hemorrhage after severe olanzapine intoxication without underlying thrombocytopenia, arterial hypertension, or vascular malformation as cause of intracerebral hemorrhage. This raises the possibility of a direct side effect of high-dose olanzapine intake. So far, intracranial hemorrhage after olanzapine intoxication in such constellation has not been reported before. Given the high number of its prescription rates, our finding of intracranial hemorrhage after olanzapine intoxication is of high clinical relevance.