A new Cu(II)-based coordination polymer: protective activity against ulcerative colitis via regulating the level of pro-inflammatory and anti-inflammatory cytokines. Issue 10 (2nd October 2020)

• Record Type: Journal Article
• Authors: Chen, Wen-Xiao; Chen, Liu; Sun, Jie; Li, Ying
• Is Part Of: Inorganic and nano-metal chemistry. Volume 50:Issue 10(2020)
• Page Start: 944
• Page End: 948
• Publication Date: 2020-10-02
• Subjects: Cu(II)-compound -- 1D framework -- nanoscale compound -- ulcerative colitis; Inorganic compounds -- Synthesis -- Periodicals; Nanostructured materials -- Periodicals; Reactivity (Chemistry) -- Periodicals; Inorganic compounds -- Synthesis; Nanostructured materials; Reactivity (Chemistry); Periodicals; 546
• DOI: 10.1080/24701556.2020.1729190
• Languages: English
• ISSNs: 2470-1556

Abstract

Abstract: A new one-dimensional (1-D) copper(II) coordination polymer, namely, {[Cu(L)(2, 2'-bipy)]·0.5DMF}n (1 ) (H2 L= 2, 2'-[benzene-1, 4-diylbis(methanediylsulfanediyl)]dibenzoic acid, 2, 2'-bipy= 2, 2'-bipyridine), has been synthesized using Cu(NO3 )2 ·3H2 O with long flexible carboxylic acids and N-containing ligands. Furthermore, a green hand grinding technique has been implemented to reduce the particle size of the compound 1 to generate nanoscale 1 (denoted as nano 1 hereafter). Furthermore, the protective effect of the compound on the ulcerative colitis was evaluated. Firstly, the Colon Tissue Mucosal Injury Score (CMDI) of the ulcerative colitis rat was measured after compound treatment. Then, the pro-inflammatory and anti-inflammatory cytokines in the UC rat model after compound treatment was measured with ELISA detection assay.