CO2-expanded liquids as solvents to enhance activity of Pseudozyma antarctica lipase B towards ortho-substituted 1-phenylethanols. Issue 42 (15th October 2020)

• Record Type: Journal Article
• Authors: Otsu, Moeko; Suzuki, Yuichi; Koesoema, Afifa Ayu; Hoang, Hai Nam; Tamura, Mayumi; Matsuda, Tomoko
• Is Part Of: Tetrahedron letters. Volume 61:Issue 42(2020)
• Publication Date: 2020-10-15
• Subjects: CO2-expanded liquid -- Lipase -- Ortho-substituted 1-phenylethanol -- Bio-based liquid; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2020.152424
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Reaction by Pseudozyma ( Candida ) antarctica lipase B (CAL-B) was examined. The limitation of CAL-B-catalyzed transesterification was solved by using CO2 . CO2 -expanded liquids, liquids dissolving pressurized CO2, were used as solvents. The reactions of ortho -substituted 1-phenylethanol analogs were accelerated. Both CO2 -expanded MeTHF and hexane were better solvents than neat MeTHF and hexane. Abstract: Pseudozyma ( Candida ) antarctica lipase B (CAL-B, Novozym 435®) is one of the most widely used and outstanding biocatalysts. However, CAL-B-catalyzed transesterification of ortho -substituted 1-phenylethanol analogs suffers low conversion. In this research, the reactions were accelerated by using CO2 -expanded liquids, liquids expanded by dissolving pressurized CO2, such as CO2 -expanded hexane or CO2 -expanded MeTHF.