Gating and calcium-sensing mechanisms of TRPA1 channels revealed. (November 2020)

• Record Type: Journal Article
• Authors: Brauchi, Sebastian E.; Rothberg, Brad S.
• Is Part Of: Cell calcium. Volume 91(2020)
• Publication Date: 2020-11
• Subjects: TRP -- Channel -- Calcium -- Mustard -- Sensory -- Pain; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2020.102278
• Languages: English
• ISSNs: 0143-4160

Abstract

Graphical abstract: Highlights: Structures of the human TRPA1 channel were solved in the presence of agonist and antagonist to reveal open and closed states. A conserved Ca 2+ modulatory site is found in a segment at the cytosolic end of the S2 and S3 transmembrane helices. We discuss insights gained from these structures toward gating and modulation in TRPA1 channels. Abstract: Novel structures of the human TRPA1 channel were determined in the presence of the agonist iodoacetamide and the antagonist A-967079, to reveal the open and closed states of the channel, respectively. The structures further revealed the location of Ca 2+ modulatory site that is likely conserved among several TRP subgroups.