Uncorking MCU to let the calcium flow. (November 2020)

• Record Type: Journal Article
• Authors: Foskett, J. Kevin
• Is Part Of: Cell calcium. Volume 91(2020)
• Publication Date: 2020-11
• Subjects: MCU -- MICU1 -- EMRE -- Mitochondria -- Cryo-EM -- Structure -- Ion channel; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2020.102257
• Languages: English
• ISSNs: 0143-4160

Abstract

Abstract: New cryo-electron microscopy structures of the mitochondrial Ca 2+ uniporter ion channel complex in various conformations reveal channel gating regulation by Ca 2+ -dependent unblock of the channel pore by MICU1.