Maternal exposure to pesticides and risk of childhood lymphoma in France: A pooled analysis of the ESCALE and ESTELLE studies (SFCE). (October 2020)

• Record Type: Journal Article
• Authors: Mavoungou, Sandra; Rios, Paula; Pacquement, Hélène; Nolla, Marie; Rigaud, Charlotte; Simonin, Mathieu; Bertrand, Yves; Lambilliotte, Anne; Faure, Laure; Orsi, Laurent; Clavel, Jacqueline; Bonaventure, Audrey
• Is Part Of: Cancer epidemiology. Volume 68(2020:Oct.)
• Publication Date: 2020-10
• Subjects: HL Hodgkin lymphoma -- NHL non-Hodgkin lymphoma; Child -- lymphoma non-Hodgkin -- Hodgkin Disease -- maternal exposure -- pesticides -- insecticides environmental exposure -- occupational exposure -- case-control studies; Cancer -- Epidemiology -- Periodicals; Cancer -- Prevention -- Periodicals; Cancer -- Diagnosis -- Periodicals; Carcinogenesis -- Periodicals; 616.994005
• DOI: 10.1016/j.canep.2020.101797
• Languages: English
• ISSNs: 1877-7821

Abstract

Highlights: Knowledge is lacking on the role of maternal pesticides use on childhood lymphoma. We pooled data from two French nationwide population-based case-control studies. Maternal insecticides use in pregnancy was associated with both NHL and HL. Associations were slightly stronger for Burkitt lymphoma and mixed cellularity HL. Abstract: Background: Few studies have assessed the relation between maternal prenatal pesticides use and childhood lymphoma risk, some reporting a positive association with non-Hodgkin lymphoma (NHL). We investigated the association between maternal exposure to pesticides during pregnancy and childhood Hodgkin (HL) and non-Hodgkin lymphoma. Methods: We pooled data from the two French national population-based case-control studies ESCALE (2003-2004) and ESTELLE (2010-2011). Data on domestic and occupational exposures to pesticides during pregnancy were obtained through standardised maternal interviews. Logistic regression models were used to compute odds ratios (OR) and 95% confidence intervals (CI) for HL and NHL, by pesticide category adjusted for potential confounders. Analyses by histological subtypes were also performed. Results: We included 328 H L, 305 non-Hodgkin NHL and 2, 415 controls. Around 40% of control mothers reported having used pesticides during index pregnancy, of whom 95% reported insecticides use. Maternal use of herbicides and fungicides occurred mostly in combination with insecticides. Insecticides use was more frequently reported in cases than controls (ORNHL = 1.6 [95%CI 1.3–2.1], p = 0.0001; ORHL = 1.3 [95%CI 1.0–1.7], p = 0.03). This association appeared more marked for Burkitt lymphoma and mixed cellularity classical HL. No obvious association was observed with occupational pesticides exposure during pregnancy. Conclusion: These results suggest that maternal domestic use of insecticides during pregnancy might be related to both childhood NHL and HL. Further larger studies are urgently needed.